Accessible standardized intracutaneous implants: Pancreatic adenocarcinoma in the Syrian hamster
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چکیده
منابع مشابه
Chemotherapy of pancreatic adenocarcinoma: initial report on two transplantable models in the Syrian hamster.
Experimental evaluation of chemotherapy of pancreatic cancer has been limited by the lack of suitable animal models, which have only recently become available. The present study is the first report on the chemosensitivity of two transplantable animal models of pancreatic adenocarcinoma. The single-agent antitumor activity of 5-fluorouracil, cyclophosphamide, mitomycin C (MMC), methotrexate, act...
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A well-differentiated ductal adenocarcinoma of the Syrian golden hamster induced by N-nitrosobis(2-oxopropyl)amine was transplantable to both nude mice and inbred Syrian hamsters. The tumor grew rapidly in the nude mouse (12-fold increase in size at 45 days) in contrast to its growth in hamster (3-fold increase in size at 45 days). A curious finding associated with the slow-growing tumor in the...
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The virus of lymphocytic choriomeningitis produces an intense systemic infection in Syrian hamsters with few if any clinical and pathological signs of disease. Specific soluble antigen is demonstrable in the spleen of infected animals until about the 14th day when antisoluble substance antibodies make their appearance. Circulating virus disappears after the 4th week and neutralizing antibodies ...
متن کاملIntussusception in the Syrian golden hamster.
Of a series of ninety-six young male Syrian Golden hamsters, 13% developed lethargy, anorexia, diarrhoea and colocolic intussusception when their diet was changed from a basal laboratory-grade rodent chow to a nutritionally complete semi-purified diet. Histologically, the colon of the hamsters with intussusception had markedly reduced mucus production. Plasma levels of gastric inhibitory polype...
متن کاملCarcinogenesis in the Syrian Golden Hamster Mutation is an Early Event in Pancreatic Duct
K-ra.v oncogene mutation has been shown to be a frequent event in pancreatic ductal adenocarcinomas induced by the carcinogen V-nitroso-bis(2-oxopropyl)amine in the hamster. The present study exam ines the mutational status of the K-r«.v oncogene in lesions that precede the appearance of invasive ductal adenocarcinomas. Syrian golden ham sters (80-100 g) received 12 weekly doses of 15 mg/kg A'...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1984
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1984.169